SCILLS - The Scottish Institute for Cell Signalling

SCILLS is dedicated to the study of how biological processes are controlled and how they become deregulated in disease. The Protein Ubiquitination Unit is the Institute’s first research Division. Its major aims are to advance understanding of the role of protein ubiquitination and related modifications in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in this process, to generate reagents and improve technologies on which more rapid progress in this area depends, and to train the next generation of scientists who will advance the subject.

Background
Research
Publications
Current Lab

Dr Gabriela Alexandru

E: g.alexandru@dundee.ac.uk

T: 44 1382 388591

F: 44 1382 388500

Dr Gabriela Alexandru

Publications

2012

Bandau, S., Knebel, A., Gage, Z.O., Wood, N.T. and Alexandru, G. (2012).
UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation. BMC Biol 10, 36.

pubmed

Alexandru, G. (2012). Exploring the role of p97 and its UBX-domain cofactors through identification of their interacting proteins. Methods Mol Biol Series, Humana Press, 832, 305-312.

pubmed

2011

Alexandru, G., Pariente, N., and Xirodimas, D. (2011). In the family with ubiquitin.
EMBO Rep 12, 880-882.

pubmed

2008

Alexandru, G., Graumann, J., Smith, G.T., Kolawa, N.J., Fang, R. and Deshaies, R.J. (2008). UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell 134, 804-816.

pubmed