SCILLS - The Scottish Institute for Cell Signalling

SCILLS is dedicated to the study of how biological processes are controlled and how they become deregulated in disease. The Protein Ubiquitination Unit is the Institute’s first research Division. Its major aims are to advance understanding of the role of protein ubiquitination and related modifications in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in this process, to generate reagents and improve technologies on which more rapid progress in this area depends, and to train the next generation of scientists who will advance the subject.

Background
Research
Publications
Current Lab

Dr Patrick G.A. Pedrioli

E: p.g.a.pedrioli@dundee.ac.uk

T: 44 1382 384784

F: 44 1382 388500

Dr Patrick G.A. Pedrioli

Publications

2010

Piwko, W., Olma, M.H., Held, M., Bianco, J.N., Pedrioli, P.G., Hofmann, K., Pasero, P., Gerlich, D.W., and Peter, M. (2010). RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells. EMBO J 29, 4210-4222.

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Bodenmiller, B., Wanka, S., Kraft, C., Urban, J., Campbell, D., Pedrioli, P.G., Gerrits, B., Picotti, P., Lam, H., Vitek, O., Brusniak, M.Y., Roschitzki, B., Zhang, C., Shokat, K.M., Schlapbach, R., Colman-Lerner, A., Nolan, G.P., Nesvizhskii, A.I., Peter, M., Loewith, R., von Mering. C., and Aebersold, R. (2010). Phosphoproteomic analysis reveals interconnected system-wide responses to perturbations of kinases and phosphatases in yeast. Sci Signal. 3, rs4.

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Jeram, S.M., Srikumar, T., Zhang, X.D., Anne Eisenhauer, H., Rogers, R., Pedrioli, P.G., Matunis, M., and Raught, B. (2010). An improved SUMmOn-based methodology for the identification of ubiquitin and ubiquitin-like protein conjugation sites identifies novel ubiquitin-like protein chain linkages. Proteomics 10, 254-265.

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Pedrioli, P.G. (2010). Trans-proteomic pipeline: a pipeline for proteomic analysis. Methods Mol Biol. 604, 213-238.

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2009

Leidel, S., Pedrioli, P.G.A., Bucher, T., Brost, R. Costanzo, M., Schmidt, A., Aebersold, R., Boone, C., Hofmann, K., and Peter, M. (2009). Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 458, 228-232.

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