SCILLS - The Scottish Institute for Cell Signalling

Goh, E.T.H., Arthur, J.F.C.,  Cheung, P.C.F., Akira, S., Toth, R. and Cohen, P. (2012). Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system. Biochem J 441, 339-346.

Clark, K., Takeuchi, O., Akira, S. and Cohen, P. (2011). TANK facilitates crosstalk within the IKK family during TLR signaling. Proc Natl Acad Sci (USA) 108, 17093-17098.

Gleason, C.E., Ordureau, A., Gourlay, R., Arthur, J.S.C. and Cohen, P. (2011) Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and the production of interferon β. J Biol Chem 286, 35663-35674

Nanda, S.K., Venigalla, R.K., Ordureau, A., Patterson-Kane, J.C., Powell, D.W., Toth, R., Arthur, J.S.C., and Cohen, P. (2011). Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med 208, 1215-1228.

Clark, K., Peggie, M., Plater, L., Sorcek, R.J., Young, E.R., Madwed, J.B., Hough, J., McIver, E.G., and Cohen, P. (2011). Novel cross-talk within the IKK family controls innate immunity. Biochem J 434, 93-104.

Smith, H., Liu, X.Y., Dai, L., Goh, E.T., Chan, A.T., Xi, J., Seh, C.C., Qureshi, I.A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E.G., Cohen, P. and Cheung, P.C.F. (2011). The role of TBK1 and IKKε in the expression and activation of Pellino 1. Biochem J 434, 537-548.

Cohen, P., and Tcherpakov, M. (2010). Will the ubiquitin system furnish as many drug targets as protein kinases? Cell 143, 686-693.

Cohen, P. (2009). Keep nibbling at the edges. J Biol Chem 284, 23891-23901.

Smith, H., Peggie, M., Campbell, D.G., Vandermoere, F., Carrick, E., and Cohen, P. (2009). Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4. Proc Natl Acad Sci USA 106, 4584-4590.

Clark, K., Plater, L., Peggie, M., and Cohen, P. (2009). Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ε: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J Biol Chem 284, 14136-14146.

Cohen, P. (2009). Targeting protein kinases for the development of anti-inflammatory drugs. Curr Opin Cell Biol 21, 317-324.

Windheim, M., Stafford, M., Peggie, M., and Cohen, P. (2008). Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IκBα kinase. Mol Cell Biol 28, 1783-1791.

Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N., and Cohen, P. (2008). The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem J 409, 43-52.

Mendoza, H., Campbell, D.G., Burness, K., Hastie, J., Ronkina, N., Shim, J.H., Arthur, J.S., Davis, R.J., Gaestel, M., Johnson, G.L., et al. (2008). Roles for TAB1 in regulating the IL-1-dependent phosphorylation of the TAB3 regulatory subunit and activity of the TAK1 complex. Biochem J 409, 711-722.

Morton, S., Hesson, L., Peggie, M., and Cohen, P. (2008). Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma. FEBS Lett 582, 997-1002.

Windheim, M., Stafford, M., Peggie, M., and Cohen, P. (2008). Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase. Mol Cell Biol 28, 1783-1791.

Windheim, M., Lang, C., Peggie, M., Plater, L.A., and Cohen, P. (2007). Molecular mechanisms involved in the regulation of cytokine production by muramyl dipeptide. Biochem J 404, 179-190.