SCILLS - The Scottish Institute for Cell Signalling

SCILLS is dedicated to the study of how biological processes are controlled and how they become deregulated in disease. The Protein Ubiquitination Unit is the Institute’s first research Division. Its major aims are to advance understanding of the role of protein ubiquitination and related modifications in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in this process, to generate reagents and improve technologies on which more rapid progress in this area depends, and to train the next generation of scientists who will advance the subject.

Background
Research
Publications
Current Lab

Dr Thimo Kurz

E: t.kurz@dundee.ac.uk

T: 44 1382 388371

F: 44 1382 388500

Dr Thimo Kurz

Publications

2011

Hjerpe, R., Thomas, Y., Chen, J. Zemla, A., Curran, S., Shpiro, N., Dick, R.L. and Kurz, T. (2011). Changes in the ratio of free Nedd8 to Ubiquitin triggers neddylation by ubiquitin enzymes. Biochem J 441, 927-936.

pubmed

Rabut, G., Le Dez, G., Verma, R., Makhnevych, T., Knebel, A., Kurz, T., Boone, C., Deshaies, R.J. and Peter, M. (2011). The TFIIH subunit Tfb3 regulates cullin neddylation. Mol Cell 5, 488-495.

pubmed

2010

Scott, D.C., Monda, J.K., Grace, C.R., Duda, D.M., Kriwacki, R.W., Kurz, T., and Schulman, B.A. (2010). A dual E3 mechanism for Rub1 ligation to Cdc53. Mol Cell 39, 784-796.

pubmed

2009

Siergiejuk, E., Scott, D.C., Schulman, B.A., Hofmann, K., Kurz, T., and Peter, M. (2009). Cullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae. EMBO J 28, 3845-3856.

pubmed

Meyer-Schaller, N., Chou, Y.C., Sumara, I., Martin, D.D., Kurz, T., Katheder, N., Hofmann, K., Berthiaume, L.G., Sicheri, F., and Peter, M. (2009). The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes. Proc Natl Acad Sci USA 106, 12365-12370.

pubmed

2008

Kurz, T., Chou, Y.C., Willems, A.R., Meyer-Schaller, N., Hecht, M.L., Tyers, M., Peter, M., and Sicheri, F. (2008). Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation. Mol Cell 29, 23-35.

pubmed